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  1. Occupational exposure to polycyclic aromatic hydrocarbons in a graphite-electrode producing plant : biological monitoring of 1-hydroxypyrene and monohydroxylated metabolites of phenanthrene.

    Article - En anglais


    The objective of this study was to assess external and internal exposure to polycyclic aromatic hydrocarbons (PAHs) of workers who are employed in a graphite-electrode producing plant.

    Additionally we wanted to contribute to the question of biological limit values in order to reduce exposure to tolerable levels.


    At five different working places 12 stationary and 16 personal air measurements were carried out to determine the concentrations of phenanthrene, fluoranthene, pyrene, benz[a]anthracene, chrysene, benzo[h]fluoranthene, benzo[a]pyrene and dibenz[a, h]anthracene in air.

    In addition, we investigated the excretion of 1-2+9-3-and 4-hydroxyphenanthrene and of 1-hydroxypyrene in the urine of 67 workers by a very sensitive and practical high-performance liquid chromatographic (HPLC) method with fluorescence detection ; 2and 9-hydroxyphenanthrene could not be separated with our analytical method.


    During the production of graphite electrodes significantly higher PAH exposures were found in the baking and impregnation area than in the crushing, graphitisation and conditioning area.

    The results of personal air measurements (mean values of the sum of eight PAHs) are : 29.3 (baking), 23.4 (impregnation), 5.2 (crushing), 1.3 (graphitisation) and 0.4 mug/m3 (conditioning).

    Stationary air measurements yielded similar concentrations.

    Workers employed in the baking and impregnation areas excreted the highest amount of PAH metabolites in urine. (...)

    Mots-clés Pascal : Hydrocarbure, Composé aromatique polycyclique, Exposition professionnelle, Médecine travail, Homme, Teneur air ambiant, Lieu travail, Surveillance biologique, Urine, Liquide biologique, Marqueur biologique, Pyrène(1-hydroxy), Phénanthrène(hydroxy)

    Mots-clés Pascal anglais : Hydrocarbon, Polycyclic aromatic compound, Occupational exposure, Occupational medicine, Human, Ambient air concentration, Work place, Biological monitoring, Urine, Biological fluid, Biological marker

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0297331

    Code Inist : 002B03L06. Création : 15/07/1997.