Changes in natural killer cell subpopulations in lead workers.
To investigate the effects of lead on human immune system, we analyzed T cell subpopulations (CD4+CD8+and CD3+cells), natural killer (NK) cell subpopulations (CD16+and CD57+cells) and B (CDl9+) cells in peripheral blood in 29 male lead workers.
All were engaged in manufacturing lead stearate in a chemical factory.
They were aged 23-74 (mean 49) years.
Their blood lead concentrations (PbB) were between 7 and 35 (mean 18) mug/dl.
They were divided into two groups according to their PbB : a high-PbB group (= 20 mug/dl), and a low-PbB group (<20 mug/dl).
The control group consisted of 19 « healthy » male workers without a history of occupational exposure to lead or to other hazardous substances, aged 48-67 (mean 58) years.
The number and percentage of CD16+cells in the high-PbB group were significantly lower than those in the controls and in the low-PbB group.
There was significant negative correlation between the number of CD16+cells and PbB in the lead workers.
The percentage of CD8+cells in the high-PbB group was larger than that in the controls and in the low-PbB group.
It is suggested that the CD16+NK cell should be a major site of the effects of lead on lymphocyte subpopulations.
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Médecine travail, Homme, Toxicité, Immunopathologie, Lymphocyte, Sous population cellulaire, Cellule NK, Japon, Asie, Antigène CD6
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Occupational medicine, Human, Toxicity, Immunopathology, Lymphocyte, Cell subpopulation, Natural killer cell, Japan, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0297328
Code Inist : 002B03L05. Création : 15/07/1997.