Alcohol, tobacco and oesophageal cancer : effects of the duration of consumption, mean intake and current and former consumption.
Numerous epidemiological studies have shown that alcohol and tobacco consumption are the main risk factors for oesophageal cancer in Western countries.
In these studies, the consumption of both alcohol and tobacco has almost always been measured as current mean intake.
The present case-control study investigates the association between alcohol and tobacco consumption and the risk of oesophageal cancer by assessing exposure as total lifetime intake, mean weekly intake, duration of consumption and former and current consumption.
Between 1991 and 1994,208 cases and 399 control subjects were selected from three French university hospitals (Caen, Dijon and Toulouse).
Eligible cases were men aged less than 85 years admitted to one of these hospitals with histologically proven squamous cell carcinoma of the oesophagus.
During the interview, complete tobacco and alcohol consumption histories were recorded.
Our findings suggest that alcohol consumption and tobacco consumption influence the risk of oesophageal cancer in different ways.
In the case of alcohol, the relationship between the odds ratio and mean weekly intake was linear, the risk depending solely on mean weekly intake, with former and current consumption having similar effects.
With regard to tobacco, the relationship between the odds ratio and mean weekly intake was log-linear ; the risk depended mainly on the duration of consumption and former consumption had a lesser effect than current consumption. (...)
Mots-clés Pascal : Carcinome épidermoïde, Oesophage, Facteur risque, Epidémiologie, Tabagisme, Alcoolisme, France, Europe, Etude cas témoin, Homme, Tumeur maligne, Appareil digestif pathologie, Oesophage pathologie
Mots-clés Pascal anglais : Squamous cell carcinoma, Esophagus, Risk factor, Epidemiology, Tobacco smoking, Alcoholism, France, Europe, Case control study, Human, Malignant tumor, Digestive diseases, Esophageal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0297113
Code Inist : 002B13A01. Création : 15/07/1997.