Recent animal studies have demonstrated three separate and distinct mechanisms by which low toxicity dusts can cause important chronic pulmonary effects ; through overloading of clearance mechanisms, through increased toxicity associated with ultrafine particle size or by increasing the toxicity of known carcinogens in mixed exposures.
The problem to be addressed is how the pathogenicity to man of various airborne dusts should be evaluated, when epidemiological evidence is often insufficient, and the reliability of extrapolation of quantitative risks from animals to man is not established.
In this paper we examine the feasibility of evaluating the likely human risks of low toxicity dusts by :
(I) semi-quantitative comparisons of the ability of various dusts, in animal studies, to cause overload of clearance and resulting inflammation and fibrosis ;
(2) postulating that these relativities apply quantitatively to human risks ;
and (3) estimating approximate human risks by comparisons with reference dusts for which adequate animal and human data are available. (...)
Mots-clés Pascal : Poussière, Toxicité, Exposition professionnelle, Médecine travail, Homme, Carcinogène, Evaluation, Risque, Animal, Pneumopathie interstitielle, Prise décision, Inflammation, Prédiction, Extrapolation animal homme, Appareil respiratoire pathologie, Particule ultrafine
Mots-clés Pascal anglais : Dust, Toxicity, Occupational exposure, Occupational medicine, Human, Carcinogen, Evaluation, Risk, Animal, Interstitial pneumonitis, Decision making, Inflammation, Prediction, Man animal extrapolation, Respiratory disease, Ultrafine particle
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0296714
Code Inist : 002B03L03. Création : 15/07/1997.