Can antimicrobial activity be sustained ? An appraisal of orally administered drugs used for respiratory tract infections.
European Congress of Chemotherapy. Glasgow, Scotland (GBR), 1996/05/16.
Respiratory tract infections (RTIs) represent a major cause of illness worldwide.
Therefore, it is of great concern that common RTI pathogens have become increasingly resistant to many of the antimicrobial agents used for therapy.
For example, Haemophilus influenzae and Moraxella catarrhalis have become resistant to beta-lactam drugs by producing efficient beta-lactamases (>35 and 90% of strains, respectively).
More recently, pneumococci have become more resistant through the mechanism of altered penicillin-binding proteins (PBPs).
The rate of penicillin nonsusceptible isolates has risen to>25% in the United States (1994-1995).
It is important to monitor the resistance characteristics of such pathogens and, if possible, to use regionally acquired data to guide empiric selection of therapeutic agents for RTIs.
Currently, some antimicrobials remain effective against the majority of these three bacterial species, as exemplified by amoxicillin/clavulanic acid.
Furthermore, amoxicillin alone seems to possess greater inhibition than other orally administered beta-lactams at clinically achievable concentrations against pneumococci with altered PBPs. (...)
Mots-clés Pascal : Bactériose, Infection, Appareil respiratoire, Homme, Traitement, Chimiothérapie, Antibactérien, Voie orale, Méthode empirique, Sensibilité résistance, Otite moyenne, Pharyngite, Appareil respiratoire pathologie, ORL pathologie, Oreille moyenne pathologie, Pharynx pathologie, Sinusite, Pneumonie
Mots-clés Pascal anglais : Bacteriosis, Infection, Respiratory system, Human, Treatment, Chemotherapy, Antibacterial agent, Oral administration, Empirical method, Sensitivity resistance, Otitis media, Pharyngitis, Respiratory disease, ENT disease, Middle ear disease, Pharynx disease, Sinusitis, Pneumonia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0291777
Code Inist : 002B02S02. Création : 15/07/1997.