Pneumococcal infections are a common cause of morbidity and mortality among elderly people.
Protection against pneumococcal infections is mediated by serotype-specific antibodies to capsular polysaccharides.
To obtain an estimate of anti-pneumococcal immunity, prevalence and levels of pneumococcal antibodies were studied in an unvaccinated elderly population.
IgG antibodies to pneumococcal serotypes 3,6A, and 8 and to cell wall polysaccharide (C-PS, a common antigen to all pneumococci) were measured by enzyme immuno-assay in 480 subjects aged 64-97 years (206 men, 274 women) who were a random sample (41%) of elderly inhabitants in a semirural community in Finland.
An average of 10% of the elderly lacked antibodies to serotypes 3,6A, and 8, and 62% of the elderly had them in low titres only.
Anti-C-PS antibodies were found in 99% of the elderly, and in significantly higher titres than anti-capsular antibodies.
Antibody titres to C-PS and to type 6A decreased with age.
Elderly women had significantly lower antibody levels than men.
Among the men, current smokers had higher antibody titres than non-smokers ; in the women, this analysis was not possible because of infrequent history of smoking.
The effect of smoking on antibody titres was reversible after cessation of smoking.
A considerable proportion of the elderly lacked protective antibodies to commonly infecting pneumococcal serotypes 3,6A, and 8. (...)
Mots-clés Pascal : Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bactérie, Anticorps, Sérologie, Age, Sexe, Tabagisme, Epidémiologie, Prévalence, Vieillard, Homme, Finlande, Europe, Appareil respiratoire pathologie, Infection
Mots-clés Pascal anglais : Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bacteria, Antibody, Serology, Age, Sex, Tobacco smoking, Epidemiology, Prevalence, Elderly, Human, Finland, Europe, Respiratory disease, Infection
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0290313
Code Inist : 002B05B02E. Création : 15/07/1997.