To evaluate a possible association between varicella-zoster virus infection and glioma, the authors asked adults with glioma (n=462) whose tumors were diagnosed between August 1,1991, and March 31,1994, and age-sex-and ethnicity-matched controls (n=443) about their histories of chickenpox or shingles.
Cases were significantly less likely than controls to report a history of either chickenpox (odds ratio=0.4,95% confidence interval (Cl) 0.3-0.6) or shingles (odds ratio=0.5,95% Cl 0.3-0.8).
To obtain serologic support for these findings, the authors conducted double-blind enzyme-linked immunosorbent assays for immunoglobulin G antibodies to varicella-zoster virus among 167 self-reporting subjects for whom blood samples were available.
Cases and controls reporting no history of chickenpox were equally likely to test positive (73% vs. 75%), but among those reporting a positive history, cases were less likely than were controls to test positive (71% vs. 85%). Despite the misclassification, an odds ratio of 0.6 was obtained using either serologic data (95% Cl 0.3-1.3) or reported history of chickenpox (95% Cl 0.3-1.1) in this subgroup of subjects.
This suggests that adults with glioma were less likely than controls either to have had prior varicella-zoster virus infection or to have an immunoglobulin G antibody response adequate to indicate positivity. (...)
Mots-clés Pascal : Gliome malin, Intracrânien, Virus varicelle, Alphaherpesvirinae, Herpesviridae, Virus, Sérologie, Epidémiologie, Facteur risque, Etiologie, Homme, Etude comparative, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Tumeur maligne
Mots-clés Pascal anglais : Malignant glioma, Intracranial, Varicella zoster virus, Alphaherpesvirinae, Herpesviridae, Virus, Serology, Epidemiology, Risk factor, Etiology, Human, Comparative study, United States, North America, America, Nervous system diseases, Central nervous system disease, Cerebral disorder, Malignant tumor
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0290311
Code Inist : 002B17E. Création : 15/07/1997.