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  1. Prevention of congenital toxoplasmosis in Szeged, Hungary.

    Article - En anglais

    Background

    Toxoplasma gondii infection of the fetus can only be discovered or prevented by the appropriate serological screening and subsequent treatment of the mother and her offspring.

    In Hungary, there is no obligatory toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is limited.

    In 1987 we started a systematic study in the Szeged region of Hungary, in which all pregnant women were screened and appropriate treatment given to all mothers and their offspring where congenital toxoplasmosis was suspected.

    Methods

    All pregnant women were routinely screened within the first 16 weeks of gestation for toxoplasma antibodies by complement fixation test (CFT).

    Seronegative cases were retested for possible seroconversion every second month.

    Patients with CFT titres = 1 

    256 were retested for anti-P30 immunoglobulin A (IgA), IgM and IgG antibodies by ELISA and/or SDS-PAGE-Western immunoblot in order to distinguish the acute and chronic phases of the infection.

    Results

    Up to the end of 1994, the sera of 17 735 gravidae were screened.

    Ten women were found to have seroconverted during pregnancy and 78 had high initial antibody levels accompanied by anti-P30 IgA antibodies at the very first screening.

    These two groups together were considered as definitely (10) or possibly (78) infected with Toxoplasma during pregnancy and were treated with Spiramycin. (...)

    Mots-clés Pascal : Toxoplasmose, Protozoose, Parasitose, Infection, Congénital, Programme sanitaire, Prévention, Diagnostic, Sérologie, Chimiothérapie, Traitement, Evaluation, Foetus, Femme, Homme, Mère, Hongrie, Europe, Maladie congénitale

    Mots-clés Pascal anglais : Toxoplasmosis, Protozoal disease, Parasitosis, Infection, Congenital, Sanitary program, Prevention, Diagnosis, Serology, Chemotherapy, Treatment, Evaluation, Fetus, Woman, Human, Mother, Hungary, Europe, Congenital disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0290110

    Code Inist : 002B20F02. Création : 15/07/1997.