Several case reports have described familial aggregation oftransitional cell carcinoma of the urinary tract but to our knowledge only 1 epidemiological study specifically addressed the issue of familial bladder cancer.
We evaluated the extent of familial aggregation of transitional cell carcinoma among the population of Iceland.
The first to third degree relatives of 190 patients with bladder, ureter or renal pelvis transitional cell carcinoma diagnosed between 1983 and 1992 in Iceland were identified through the Icelandic Cancer Family Resource.
The records of these 12,328 relatives were subsequently linked to the 1965 to 1994 cancer registry.
The observed occurrence of transitional cell carcinoma of the urinary tract was compared to the expected occurrence based on age, gender and calendar specific incidence rates.
Observed-to-expected ratios and 95% confidence intervals were calculated.
In 41 of the 190 pedigrees at least 1 relative had transitional cell carcinoma of the urinary tract.
Of the probands 38 had only 1 and 3 had 2 affected relatives.
The prevalence of family history of transitional cell carcinoma was 3% in first degree and 10% in first or second degree relatives.
The risk of transitional cell carcinoma among all relatives was slightly elevated (observed-to-expected ratio 1.24,95% confidence interval 0.90 to 1.67). (...)
Mots-clés Pascal : Carcinome cellule transitionnelle, Voie urinaire, Vessie urinaire, Islande, Iles Atlantiques, Epidémiologie, Facteur risque, Homme, Tumeur maligne, Appareil urinaire pathologie, Voie urinaire pathologie, Vessie pathologie, Maladie héréditaire
Mots-clés Pascal anglais : Transitional cell carcinoma, Urinary tract, Urinary bladder, Iceland, Atlantic Ocean Islands, Epidemiology, Risk factor, Human, Malignant tumor, Urinary system disease, Urinary tract disease, Bladder disease, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0289000
Code Inist : 002B14D02. Création : 15/07/1997.