logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Survival of AIDS patients according to type of AIDS-defining event.

    Article - En anglais

    Background

    There are known to be wide differences in the prognosis of patients with a diagnosis of AIDS.

    In this study of 6578 patients with AIDS from 17 European centres, we develop a ranking of AIDS-defining illnesses, and determine how well this ranking holds after adjustment for potential confounding variables.

    Methods

    Survival from each AIDS-defining event was calculated and ranked using Kaplan-Meier estimation of median survival.

    Cox proportional hazards models with each disease modelled as a time dependant covariate were used to determine the risk of death after each diagnosis, before and after adjustment for potential confounders.

    Results

    Median survival after an initial AIDS-defining diagnosis of progressive multifocal leukoencephalopathy and malignant lymphoma was particularly poor (2 and 5 months respectively), while the longest median survival occurred after initial AIDS-defining illnesses of Kaposi's sarcoma and extrapulmonary tuberculosis (17 and 22 months respectively).

    Patients diagnosed with a primary brain lymphoma had shorter median survival times than patients with a peripheral lymphoma (median survival of 1 month and 4 months respectively, P<0.0001).

    In general, median survival in patients with cutaneous Kaposi's sarcoma (skin, oral) was between two and four times longer than patients with systemic involvement.

    The ranking of diseases was found to be generally similar after adjustment for all potential confounders.

    Conclusions

    (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Survie, Classification, Complication, Epidémiologie, Pronostic, Homme, Europe, Etude multicentrique, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Survival, Classification, Complication, Epidemiology, Prognosis, Human, Europe, Multicenter study, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0288709

    Code Inist : 002B06D01. Création : 15/07/1997.