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  1. Fulltext. The effect of postmenopausal estrogen therapy on the risk of non-insulin-dependent diabetes mellitus.

    Article - En anglais

    Fulltext.

    Objectives

    This study examined the effect of postmenopausal estrogen replacement therapy on the incidence of non-insulin-dependent diabetes in women.

    Methods

    Postmenopausal women aged 50 through 70 years (n=848) without diagnosed diabetes at baseline were followed for 10 to 15 years for incident diabetes.

    Results

    Over the average 11.5 year follow-up, there were 105 new cases of diabetes.

    The age-adjusted relative-risk for development of diabetes was nonsignificantly lower for women with continuous estrogen replacement therapy use than for never users.

    After adjustment for major covariates, a nonsignificant linear trend with increasing duration of estrogen replacement therapy was reversed.

    Conclusions

    This study suggests that previous results showing a reduced risk of diabetes in women using estrogen may have been due to selection bias regarding who is prescribed estrogen, confounding factors, or differential diagnostic efforts.

    Mots-clés Pascal : Diabète non insulinodépendant, Traitement substitutif, Oestrogène, Postménopause, Hormone stéroïde sexuelle, Chimiothérapie, Epidémiologie, Incidence, Facteur risque, Toxicité, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Etude cohorte, Endocrinopathie

    Mots-clés Pascal anglais : Non insulin dependent diabetes, Replacement therapy, Estrogen, Postmenopause, Sex steroid hormone, Chemotherapy, Epidemiology, Incidence, Risk factor, Toxicity, Human, Female, United States, North America, America, Cohort study, Endocrinopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0288617

    Code Inist : 002B02U10. Création : 15/07/1997.