The effect of postmenopausal estrogen therapy on the risk of non-insulin-dependent diabetes mellitus.
This study examined the effect of postmenopausal estrogen replacement therapy on the incidence of non-insulin-dependent diabetes in women.
Postmenopausal women aged 50 through 70 years (n=848) without diagnosed diabetes at baseline were followed for 10 to 15 years for incident diabetes.
Over the average 11.5 year follow-up, there were 105 new cases of diabetes.
The age-adjusted relative-risk for development of diabetes was nonsignificantly lower for women with continuous estrogen replacement therapy use than for never users.
After adjustment for major covariates, a nonsignificant linear trend with increasing duration of estrogen replacement therapy was reversed.
This study suggests that previous results showing a reduced risk of diabetes in women using estrogen may have been due to selection bias regarding who is prescribed estrogen, confounding factors, or differential diagnostic efforts.
Mots-clés Pascal : Diabète non insulinodépendant, Traitement substitutif, Oestrogène, Postménopause, Hormone stéroïde sexuelle, Chimiothérapie, Epidémiologie, Incidence, Facteur risque, Toxicité, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Etude cohorte, Endocrinopathie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Replacement therapy, Estrogen, Postmenopause, Sex steroid hormone, Chemotherapy, Epidemiology, Incidence, Risk factor, Toxicity, Human, Female, United States, North America, America, Cohort study, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0288617
Code Inist : 002B02U10. Création : 15/07/1997.