Background It has been hypothesized that asthma-related health problems are most severe among children in inner-city areas who are allergic to a specific allergen and also exposed to high levels of that allergen in bedroom dust.
Methods From November 1992 through October 1993, we recruited 476 children with asthma (age, four to nine years) from eight inner-city areas in the United States.
Immediate hypersensitivity to cockroach, house-dust-mite, and cat allergens was measured by skin testing.
We then measured major allergens of cockroach (Bla g 1), dust mites (Der p 1 and Der f 1), and cat dander (Fel d 1) in household dust using monoclonal-antibody-based enzyme-linked immunosorbent assays.
High levels of exposure were defined according to proposed thresholds for causing disease.
Data on morbidity due to asthma were collected at base line and over a one-year period.
Results Of the children, 36.8 percent were allergic to cockroach allergen, 34.9 percent to dust-mite allergen, and 22.7 percent to cat allergen.
Among the children's bedrooms, 50.2 percent had high levels of cockroach allergen in dust, 9.7 percent had high levels of dust-mite allergen, and 12.6 percent had high levels of cat allergen.
After we adjusted for sex, score on the Child Behavior Checklist, and family history of asthma, we found that children who were both allergic to cockroach allergen and exposed to high levels of this allergen had 0.37 hospitalization a year, as compared with 0. (...)
Mots-clés Pascal : Asthme, Allergie, Facteur risque, Allergène, Degré exposition, Association, Test cutané, Etude comparative, Evaluation, Enfant, Homme, Centre ville, Internat, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Cockroach
Mots-clés Pascal anglais : Asthma, Allergy, Risk factor, Allergen, Degree of exposure, Association, Skin test, Comparative study, Evaluation, Child, Human, City center, Boarding school, Respiratory disease, Obstructive pulmonary disease, Immunopathology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0288575
Code Inist : 002B11B. Création : 15/07/1997.