Prostate-specific antigen velocity (PSAV), or rate of change in PSA, is a concept that considers the changes in PSA between measurements adjusted for the elapsed time between the measurements.
Because there is substantial individual variability between PSA measurements, a simple change in PSA is not useful as a marker for prostate cancer ; however, studies suggest that if PSAV is evaluated during at least 1.5 to 2 years, (1) less than 5% of men without prostate cancer have a PSAV of 0.75 ng/mL per year or more and (2) more than 70% of men with prostate cancer have a PSAV of 0.75 ng/mL per year or more.
These data suggest that PSAV is a specific marker for prostate cancer that can be used as one method for assessing the risk that prostate cancer is present.
Mots-clés Pascal : Adénocarcinome, Prostate, Marqueur tumoral, Antigène spécifique prostate, Dépistage, Valeur prédictive, Vitesse, Variation, Taux concentration, Intérêt, Etude statistique, Homme, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie, Biologie
Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Tumoral marker, Prostate specific antigen, Medical screening, Predictive value, Velocity, Variations, Concentration factor, Interest, Statistical study, Human, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease, Biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0288443
Code Inist : 002B14D02. Création : 15/07/1997.