Limitations in sensitivity and specificity have prevented prostate-specific antigen (PSA) from becoming the ideal tumor marker for the diagnosis of early, curable prostate cancer.
The recent demonstration of a direct correlation between PSA and patient age has resulted in age-specific reference ranges that enhance the sensitivity of PSA in younger men, while improving the specificity of PSA in older men.
Age-specific reference ranges also have been determined for Japanese and African-American men.
Finally, the effect of age on the different molecular forms of PSA has been established.
Taken together, this information definitely has enhanced the diagnostic utility of PSA in the detection of prostate cancer.
Mots-clés Pascal : Adénocarcinome, Prostate, Marqueur tumoral, Antigène spécifique prostate, Dépistage, Relation, Taux concentration, Age, Evolution, Norme, Etude statistique, Homme, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie, Biologie
Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Tumoral marker, Prostate specific antigen, Medical screening, Relation, Concentration factor, Age, Evolution, Standards, Statistical study, Human, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease, Biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0288442
Code Inist : 002B14D02. Création : 15/07/1997.