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  1. Molecular forms of serum prostate-specific antigen : The clinical value of percent free prostate-specific antigen : Prostate-specific antigen : the best prostatic tumor marker.

    Fascicule - En anglais

    It is well established that prostate-specific antigen (PSA) exists in the seminal fluid and serum in several different forms.

    Patients with prostate cancer have more of the form, in which PSA is bound to alpha-1-antichymotrypsin, and men without benign prostatic hyperplasia (BPH) have more of the free form.

    As a result, it is suggested that determining the percent free PSA value might be useful in distinguishing men with early, curable prostate cancer from men with BPH only.

    Percent free PSA is likely to have its greatest clinical impact when the total PSA value ranges from 2.5 to 3.0 ng/mL at the low end to 10.0 ng/mL at the high end.

    Mots-clés Pascal : Adénocarcinome, Prostate, Marqueur tumoral, Antigène spécifique prostate, Dépistage, Isozyme, Ratio, Forme libre, Valeur prédictive, Intérêt, Spécificité, Etude statistique, Homme, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie, Biologie

    Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Tumoral marker, Prostate specific antigen, Medical screening, Isozyme, Ratio, Free form, Predictive value, Interest, Specificity, Statistical study, Human, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease, Biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0288414

    Code Inist : 002B14D02. Création : 15/07/1997.