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  1. Childhood hemolytic uremic syndrome in Argentina : long-term follow-up and prognostic features.

    Article - En anglais

    From January 1968 to December 1984,312 infants and children with hemolytic uremic syndrome were admitted to our unit ; 8 patients died (2.5%) during the acute phase ; 118 children were followed as outpatients at yearly intervals for at least 10 years (mean follow-up 13 years, range 10-19.8 years).

    Four evolution patterns at the end of the follow-up were defined :

    • group 1, complete recovery, 74 (62.7%) ;

    • group 2, proteinuria with/without hypertension, 21 (17.7%) ;

    • group 3, reduced creatinine clearance, often in conjunction with proteinuria and hypertension, 19 (16.1%) ;

    • group 4, end-stage renal failure, 4 (3.4%). We investigated the association between several variables of the acute stage and the long-term evolution.

    Most non-anuric patients recovered completely (92.5%), while 38.4% of those with 1-10 days and 69.2% of those with 11 or more days of anuria had chronic renal sequelae.

    Similar results were found when analyzing the requirement for peritoneal dialysis.

    Of the patients with proteinuria at the 1-year control, 86% had renal abnormalities at the end of the follow-up.

    In our experience, although the final outcome was not predictable in every instance, the severity of acute renal failure - as determined by the days of anuria - and the presence of proteinuria 1 year after the acute phase were the most useful prognostic indicators.

    Mots-clés Pascal : Hémolyse urémie, Fonction rénale, Etude longitudinale, Pronostic, Exploration, Epidémiologie, Enfant, Homme, Argentine, Amérique du Sud, Amérique, Insuffisance rénale, Appareil urinaire pathologie, Hémopathie, Anémie hémolytique, Rein pathologie

    Mots-clés Pascal anglais : Hemolytic uremic syndrome, Renal function, Follow up study, Prognosis, Exploration, Epidemiology, Child, Human, Argentina, South America, America, Renal failure, Urinary system disease, Hemopathy, Hemolytic anemia, Kidney disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0288255

    Code Inist : 002B14A05. Création : 15/07/1997.