In Orebro County a 2.5-fold increase in the incidence of Haemophilus influenzae (HI) meningitis was found between 1970 and 1980, an observation that initiated the present study.
In order to search for associations between morbidity in invasive HI infection and possible risk factors, a case-control study was conducted over a 6-year period from 1987 to 1992, before general Hib vaccination was introduced in Sweden.
Fifty-four cases with invasive HI infection and 139 matched controls were studied for possible risk factors such as day-care outside the home, short duration of breastfeeding, passive smoking, low socioeconomic level of the household, many siblings in the family, allergy, frequent infections, repeated antibiotic treatments and immunoglobulin deficiency.
Multivariate analysis showed a significant association between invasive HI infection and two independent factors, i.e. short duration (<13 weeks) of exclusive breastfeeding, odds ratio (OR) 3.79 (95% confidence interval [Cl] 1.6-8.8) and history of frequent infections, OR 4.49 (95% Cl : 1.0-21.0).
For the age at onset 12 months or older, the associations were stronger, OR 7.79 (95% Cl : 2.4-26.6) and 5.86 (95% Cl : 1.1-30.6), respectively.
When breastfeeding duration in weeks was analysed as a continuous variable the OR was 0.95 (95% Cl : 0.92-0.99), indicating a decreased risk with each additional week. (...)
Mots-clés Pascal : Allaitement, Haemophilus influenzae, Pasteurellaceae, Bactérie, Infection, Méningite, Epidémiologie, Protection, Incidence, Enfant, Homme, Age préscolaire, Suède, Europe, Etude cas témoin, Système nerveux pathologie, Système nerveux central pathologie
Mots-clés Pascal anglais : Breast feeding, Haemophilus influenzae, Pasteurellaceae, Bacteria, Infection, Meningitis, Epidemiology, Protection, Incidence, Child, Human, Preschool age, Sweden, Europe, Case control study, Nervous system diseases, Central nervous system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0288211
Code Inist : 002B05C02A. Création : 15/07/1997.