With the aim of elucidating the relationships between breast cancer, risk factors and benign breast changes, extratumoral breast tissue in 1,506 women from the WHO Collaborative study of neoplasia and steroid contraceptives was studied histologically.
Patients came from 3 countries with a high incidence of breast cancer (Israel, East Germany and Australia) and 6 low-risk countries (Thailand, China, Philippines, Mexico, Chile and Colombia).
Ductal atypia, ductal hyperplasia, adenosis, lobular atypia, apocrine metaplasia, apocrine hyperplasia, apocrine atypia, cysts, duct ectasia, inflammatory reaction, calcification, lactational change and epithelial-stromal ratio were classified as absent/mild/moder-atelmarked.
Prevalence odds ratios were calculated by logistic regression analyses.
Increasing frequency with age was found for ductal hyperplasia, sclerosing adenosis, apocrine metaplasia and cysts, while adenosis, lactational change and the epithelial-stromal ratio decreased with age.
No significant difference between high-and low-risk countries was found for ductal hyperplasia or sclerosing adenosis.
Compared with cases from high-risk countries, those from low-risk countries had a significantly lower prevalence of apocrine metaplasia, apocrine hyperplasia and cysts, and a significantly higher prevalence of ductal atypia. (...)
Mots-clés Pascal : Carcinome, Glande mammaire, Homme, Epidémiologie, Facteur risque, Lésion précancéreuse, Tumeur bénigne, Association, Histopathologie, Prévalence, Etude multicentrique, Echelon international, Femelle, Région géographique, Age, Tumeur maligne, Glande mammaire pathologie, Anatomopathologie, Tissu extratumoral
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Human, Epidemiology, Risk factor, Premalignant lesion, Benign neoplasm, Association, Histopathology, Prevalence, Multicenter study, International scope, Female, Geographical division, Age, Malignant tumor, Mammary gland diseases, Pathology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0287703
Code Inist : 002B20E02. Création : 15/07/1997.