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  1. Family size, atopic disorders in parents, asthma in children, and ethnicity.

    Article - En anglais

    Background 

    Several studies have reported an association between family size and atopic conditions, but few have found an association between asthma and family size.

    Objective 

    This study was designed to assess the effect of familial aggregation and sibling number on asthma in children.

    Methods 

    Children from 5 to 11 years of age in England and Scotland participated in a study in 1990 or 1991 in which responses to questions on asthma and wheezing in children and atopic conditions in parents were ascertained.

    Data on 11,924 complete family sets of child, mother, and father in three samples (the « representative » samples of England and Scotland and the English « inner city » sample) were analyzed.

    Results 

    The following factors were highly associated with child's asthma or wheezing : mother's or father's asthma or wheezing (with the same odds ratio [OR], 2.4 ; 95% confidence interval [CI], 2.0 to 2.9), other atopic condition in mothers and fathers (OR, 1.5 ; 95% CI, 1.3 to 1.8 and OR, 1.4 ; 95% CI, 1.2 to 1.7, respectively), and three or more siblings compared with no siblings (OR, 0.5 ; 95% CI, 0.4 to 0.6).

    Conclusion 

    The negative relation between family size and wheezing or asthma indicates a protective effect of number of children sharing an environment at a young age. (...)

    Mots-clés Pascal : Asthme, Prévalence, Epidémiologie, Dimension famille, Atopie, Parent, Ethnie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Ecosse, Enfant, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Allergie, Immunopathologie

    Mots-clés Pascal anglais : Asthma, Prevalence, Epidemiology, Family size, Atopy, Parent, Ethnic group, England, Great Britain, United Kingdom, Europe, Scotland, Child, Human, Respiratory disease, Obstructive pulmonary disease, Allergy, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0287448

    Code Inist : 002B11B. Création : 15/07/1997.