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  1. Cancer risk assessment using blood dioxin levels and daily dietary TEQ intake in general populations of industrial and non-industrial countries.

    Article, Communication - En anglais

    Chlorinated Dioxins, PCB and Related Compounds 1995. international Symposium. Edmonton (CAN), 1995/08/21.

    We previously measured polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in U.S. foods and estimated the daily dioxin toxic equivalent (TEQ) intake to be from 0.3 to 3.0 pgI-TEQ/kg body weight for adults.

    These values are similar to values reported in Canada, Germany, England, and the Netherlands.

    The U.S. Environmental Protection Agency (EPA) Dioxin Reassessment Draft Documents currently propose a cancer risk-specific dose estimate of 0.01 pg TEQ/kg body weight/day (U.S. EPA, 1994).

    This risk-specific dose estimate represents a lifetime (70 years) dose which results in a plausible upper bound cancer risk of 1 x 10-6 (the probability of one additional cancer per one million exposed population over a lifetime).

    The proximate source of almost all dioxin intake in the general population is from food.

    Using our data for daily dietary dioxin exposure and the EPA's proposed risk specific dose, we estimate that over a lifetime a maximum of 30 to 300 excess cancers per million could result from the ingestion of dioxin containing food products.

    In the U.S. population of 260 million, a maximum range of 7,800 to 78,000 excess cancers over a lifetime (70 years) or 111 to 1,114 cases/year might be directly linked to dioxin exposure from food.

    Because these calculations are based on conservative approaches to setting an upper bound, « true » risk is not likely to exceed this value. (...)

    Mots-clés Pascal : Analyse risque, Carcinogène, Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Dibenzofurane(polychloro), Chlore Composé organique, Hétérocycle oxygène, Aliment, Etats Unis, Amérique du Nord, Amérique, Organisme réglementation, Régime alimentaire, Pays industrialisé, Pays en développement, Facteur équivalence toxique

    Mots-clés Pascal anglais : Risk analysis, Carcinogen, Chlorine Organic compounds, Oxygen heterocycle, Food, United States, North America, America, Regulatory institution, Diet, Industrialized country, Developing countries, Toxic equivalency factor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0287110

    Code Inist : 002B04E05. Création : 15/07/1997.