This study assesses the effect of chronic hypertension on fetal growth.
A cohort of 1,938 pregnant women attending five prenatal clinics in France between August 1991 and May 1993 were enrolled in a prospective study.
Chronic hypertension was defined according to blood pressure at enrollment and past history, and cases complicated by preeclampsia were excluded.
Adjusted odds ratios of small-for-gestational age birth were estimated by logistic regression.
The independent effect of chronic hypertension on mean birth weight was examined through multiple linear regression analysis adjusting for gestational age at delivery and potential confounders.
Uncomplicated chronic hypertension was associated with an increased risk of small-for-gestational age birth.
Odds ratios increased with age.
In women over age 30 years, the association was strong (adjusted odds ratio=8.5,95% confidence interval 2.9-24.5).
Multiple linear regression showed that mean birth weight was 161 g (95% confidence interval 66-256 g) less in women with chronic hypertension compared with normotensive women.
The authors conclude that mean birth weight is reduced and the risk of small-for-gestational age birth is increased in uncomplicated chronic hypertension compared with normotensive pregnancies.
Results further suggest that the magnitude of this association increases with age.
Mots-clés Pascal : Poids naissance faible, Epidémiologie, Hypertension artérielle, Gestation, Mère, Chronique, France, Europe, Nouveau né, Homme, Prospective, Etude cohorte, Gestation pathologie, Prématurité, Nouveau né pathologie, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Low birth weight, Epidemiology, Hypertension, Pregnancy, Mother, Chronic, France, Europe, Newborn, Human, Prospective, Cohort study, Pregnancy disorders, Prematurity, Newborn diseases, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0281842
Code Inist : 002B20G02. Création : 15/07/1997.