Dose-response associations of silica with nonmalignant respiratory disease and lung cancer mortality in the diatomaceous earth industry.
The potential carcinogenicity of crystalline silica to humans remains a controversial issue.
The authors conducted an historical cohort mortality study of 2,342 male workers exposed to crystalline silica, predominantly cristobalite, in a diatomaceous earth mining and processing facility in California.
During the years 1942-1994, mortality excesses were detected for nonmalignant respiratory diseases (NMRD) (standardized mortality ratio=2.01,95% confidence interval (CI) 1.56-2.55) and lung cancer (standardized mortality ratio=1.29,95% CI 1.01-1.61).
NMRD mortality rose sharply with cumulative exposure to respirable crystalline silica ; allowing for a 15-year latency, the rate ratio for the highest exposure stratum (=5.0 mg/m3-years) was 5.35 (95% Cl 2.23-12.8).
The rate ratio for lung cancer reached 2.15 (95% CI 1.08-4.28) in the highest exposure category.
These associations were unlikely to have been confounded by smoking or asbestos exposure.
The findings indicate a strong dose-response relation for crystalline silica and NMRD mortality.
The lung cancer results, although less convincing, add further support to an etiologic role for crystalline silica.
Mots-clés Pascal : Silice, Epidémiologie, Industrie extractive, Exposition professionnelle, Toxicité, Tumeur maligne, Bronchopulmonaire, Mortalité, Homme, Etude cohorte, Etude longitudinale, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Terre diatomées
Mots-clés Pascal anglais : Silica, Epidemiology, Mining industry, Occupational exposure, Toxicity, Malignant tumor, Bronchopulmonary, Mortality, Human, Cohort study, Follow up study, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0281841
Code Inist : 002B03L05. Création : 15/07/1997.