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  1. Coal mine workers'pneumoconiosis.

    Article - En anglais

    The fibrogenic and cytotoxic potential of coal mine dust is independent of the amount of quartz and other inorganic parameters.

    Results of coal petrographical and organic geochemical investigations of coals and coal mine dust from the Ruhr and Ibbenbüren Region of Germany demonstrate variations of organic dust amount possibly influencing these noxious properties.

    Coal mine dust of high rank coals is characterized by a pronounced fibrogenic risk.

    This risk, independent of the quantity of quartz, is probably based on shape variations of different coal macerals.

    With increasing coalification of the corresponding seam, the vitrinite is enriched in its dust ; however, lower concentrations have been determined for inertinite.

    Vitrinite shows constant shapes and sizes independent of the rank of coal.

    Inertinite particles with elongated to fibrous shapes tend to larger sizes with increasing coalification.

    Strikingly, coal mine dust from miners'lungs with high degrees of coal mine workers'pneumoconiosis (CWP) is enriched in inertinite.

    In contrast, high cytotoxicities in cell tests are known for coal mine dust from low coalified coals.

    High concentrations of phenolic compounds can be extracted by dichloromethane from low coalified coal mine dust.

    These compounds, which are characterized by a high water solubility and therefore high bioavailability, explain the high cytotoxicities of coal mine dust. (...)

    Mots-clés Pascal : Mine charbon, Industrie extractive, Exposition professionnelle, Médecine travail, Homme, Pneumoconiose, Poussière, Quartz, Allemagne, Europe, Autopsie, Poumon, Fibrose, Toxicité, Pétrographie, Appareil respiratoire pathologie, Poumon pathologie, Méthodologie

    Mots-clés Pascal anglais : Coal mine, Mining industry, Occupational exposure, Occupational medicine, Human, Pneumoconiosis, Dust, Quartz, Germany, Europe, Autopsy, Lung, Fibrosis, Toxicity, Petrography

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0277542

    Code Inist : 002B03L03. Création : 15/07/1997.