The role of multi-centre cohort studies in studying the relation between diet and cancer.
International Congress on Food and Cancer Prevention. Ede (NLD), 1996/05/19.
In spite of important progress made during recent decades in nutritional epidemiology methods, many questions about the role of diet in determining cancer risk remain elusive.
One example of an unresolved question is whether a high percentage of energy intake in the form of fat (especially saturated fat) is associated with an increased risk of breast cancer.
Observations from international correlation and case-control studies support this hypothesis, while results from prospective cohort studies, generally considered less prone to bias, do not.
In this paper, we review the advantages and limitations of these different types of epidemiological study design, and discuss how multi-centre studies may help answer some of the unresolved questions about relations between diet, nutritional status, and cancer risk.
Multi-centre cohort studies may have the advantage of increased statistical power because of larger variations in individuals'dietary intake patterns and disease risk (as in international correlation studies), while at the same time offering all the possibilities of individual-level studies to model confounding and/or interaction effects.
Mots-clés Pascal : Epidémiologie, Régime alimentaire, Aliment, Carcinogène, Tumeur maligne, Etude cas témoin, Etude cohorte, Métaanalyse, Etude multicentrique, Facteur risque
Mots-clés Pascal anglais : Epidemiology, Diet, Food, Carcinogen, Malignant tumor, Case control study, Cohort study, Metaanalysis, Multicenter study, Risk factor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0276151
Code Inist : 002B04E05. Création : 15/07/1997.