Interplay of cigarette smoking and occupational exposure on specific immunoglobulin E antibodies to cobalt.
The results of a cross-sectional survey of an occupational population (n=706) exposed to hard metal dust revealed distribution of specific immunoglobulin E antibodies against cobalt-conjugated serum albumin (Co-HSA).
This population was segregated with respect to smoking and dust-exposure doses.
Standard deviations (0.08-0.13) of Co-HSA RAST were sufficiently small (<7%) to warrant reproducibility.
Confirming evidence for 8 workers who had mean+3 standard deviations of Co-HSA RAST indices and who had been diagnosed with occupational asthma also provided better sensitivity (8/19) and specificity (687/687) of hard metal asthma, rather than metal-induced asthma.
Cobalt exposure resulted in significant increases in Co-HSA RAST indices in males, whose mean index was 1.16 ± 0.13 in nonexposed subjects and 1.37 ± 0.13 in exposed subjects.
There was no difference, however, in the females.
This difference between males and females cannot be explained by differences in ages or dust-exposure doses.
Furthermore, the specific RAST indices against Co-HSA displayed a strong correlation not only to the intensity of cobalt exposure (r=488, p<. 001), but to log (total exposure doses) (r=578, p<. 001).
These results suggest that Co-HSA RAST might be useful as a biological marker for the allergic etiology of hard metal asthma.
Nonexposed smokers had similar mean RAST indices : 1.18 ± 0.12 lU/ml, compared with 1.15 ± 0.16 lU/ml for nonexposed subjects who had never smoked. (...)
Mots-clés Pascal : Tabagisme, Exposition professionnelle, Médecine travail, Métal fritté, Cobalt, Poussière, Sérumalbumine, Conjugaison, Anticorps, IgE, Prévention, Asthme, Homme, Appareil respiratoire pathologie, Association toxique
Mots-clés Pascal anglais : Tobacco smoking, Occupational exposure, Occupational medicine, Sintered metal, Cobalt, Dust, Serum albumin, Conjugation, Antibody, IgE, Prevention, Asthma, Human, Respiratory disease, Toxic association
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0275636
Code Inist : 002B03E. Création : 15/07/1997.