logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Interplay of cigarette smoking and occupational exposure on specific immunoglobulin E antibodies to cobalt.

    Article - En anglais

    The results of a cross-sectional survey of an occupational population (n=706) exposed to hard metal dust revealed distribution of specific immunoglobulin E antibodies against cobalt-conjugated serum albumin (Co-HSA).

    This population was segregated with respect to smoking and dust-exposure doses.

    Standard deviations (0.08-0.13) of Co-HSA RAST were sufficiently small (<7%) to warrant reproducibility.

    Confirming evidence for 8 workers who had mean+3 standard deviations of Co-HSA RAST indices and who had been diagnosed with occupational asthma also provided better sensitivity (8/19) and specificity (687/687) of hard metal asthma, rather than metal-induced asthma.

    Cobalt exposure resulted in significant increases in Co-HSA RAST indices in males, whose mean index was 1.16 ± 0.13 in nonexposed subjects and 1.37 ± 0.13 in exposed subjects.

    There was no difference, however, in the females.

    This difference between males and females cannot be explained by differences in ages or dust-exposure doses.

    Furthermore, the specific RAST indices against Co-HSA displayed a strong correlation not only to the intensity of cobalt exposure (r=488, p<. 001), but to log (total exposure doses) (r=578, p<. 001).

    These results suggest that Co-HSA RAST might be useful as a biological marker for the allergic etiology of hard metal asthma.

    Nonexposed smokers had similar mean RAST indices : 1.18 ± 0.12 lU/ml, compared with 1.15 ± 0.16 lU/ml for nonexposed subjects who had never smoked. (...)

    Mots-clés Pascal : Tabagisme, Exposition professionnelle, Médecine travail, Métal fritté, Cobalt, Poussière, Sérumalbumine, Conjugaison, Anticorps, IgE, Prévention, Asthme, Homme, Appareil respiratoire pathologie, Association toxique

    Mots-clés Pascal anglais : Tobacco smoking, Occupational exposure, Occupational medicine, Sintered metal, Cobalt, Dust, Serum albumin, Conjugation, Antibody, IgE, Prevention, Asthma, Human, Respiratory disease, Toxic association

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0275636

    Code Inist : 002B03E. Création : 15/07/1997.