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  1. Associations of subtypes of hemoglobin with delta-aminolevulinic acid dehydratase genotype and dimercaptosuccinic acid-chelatable lead levels.

    Article - En anglais

    Hemoglobin in erythrocytes may be an important intravascular site of lead binding.

    We examined associations of hemoglobin subtypes A1 and A2 with delta-aminolevulinic acid dehydratase (ALAD) genotype, a protein that is another important site of erythrocyte lead binding.

    After oral administration of dimercaptosuccinic acid (DMSA-chelatable lead), we also examined 4-h lead excretion, which provides an estimate of bioavailable lead stores.

    We randomly selected 57 South Korean current lead battery manufacturing workers from two plants (N=290 employees) and from two ALAD genotype strata (ALAD1-1 and ALAD1-2).

    These workers voluntarily administered 5 mg/kg oral DMSA.

    We frequency-matched subjects with ALAD1-1 (n=38) to subjects with ALAD1-2 (n=19) with respect to duration of employment in the lead industry.

    Blood lead levels ranged from 11 to 53 mug/dl (mean ± standard deviation, 25.4 ± 10.2 mug/dl).

    After administration of oral DMSA, workers excreted a mean lead level of 85.4 (standard deviation, 45.0 mug ; range, 16.5-184.1 mug).

    Hemoglobin A1 and A2 ranged from 3.7% to 9.9% and 1.6% to 5.9%, respectively (mean ± standard deviation, 6.2 ± 1.0% and 2.7 ± 0.8%, respectively).

    Subjects with ALAD1-1 had elevated mean hemoglobin A1 levels (adjusted p=05).

    In addition, higher hemoglobin A1 levels were associated with higher DMSA-chelatable lead levels (adjusted p=03). (...)

    Mots-clés Pascal : Plomb, Métal lourd, Pharmacocinétique, Toxicocinétique, Fixation biologique, Hémoglobine, Erythrocyte, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Enzyme, Succimer, Chélateur, Homme, Exposition professionnelle, Médecine travail, Corée du Sud, Corée, Asie, Génétique, Comparaison interindividuelle, Génotype, Site fixation, Polymorphisme, DMSA

    Mots-clés Pascal anglais : Lead, Heavy metal, Pharmacokinetics, Toxicokinetics, Biological fixation, Hemoglobin, Red blood cell, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Enzyme, Succimer, Chelating agent, Human, Occupational exposure, Occupational medicine, South Korea, Korea, Asia, Genetics, Interindividual comparison, Genotype, Binding site, Polymorphism

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0275635

    Code Inist : 002B03L05. Création : 15/07/1997.