Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women.
Factor V Leiden (factor V Arg506Gln), the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis.
The relationship between this genetic abnormality and arterial disease is still unresolved.
To assess whether factor V Leiden increases the risk of myocardial infarction (M1), we conducted a population-based case-control study among women 18 to 44 years of age in western Washington state.
We included 84 women with first Ml and 388 control women, ie, women residing in the same area in the same age range without Ml (n=388).
The control women were contacted by random digit dialing.
Data on risk factor status were collected via personal interview, and data on the factor V genotype via polymerase chain reaction techniques.
The factor V Leiden mutation was found more often in women with Ml (10%) than among controls (4%). The odds ratio for Ml was 2.4 [95% confidence interval (Cl) 1.0 to 5.9]. The risk was increased fourfold (Clgs 1.2 to 12.1) when adjusted for major cardiovascular risk factors.
Among nonsmokers the factor V Leiden mutation had little effect (odds ratio 1.1, Cl95 0.1 to 8.5), whereas it had a large effect among smokers (odds ratio 3.6, C195 0.9 to 14.4), which, because smoking was itself a strong risk factor for Ml, led to an odds ratio for smoking carriers of the mutation that was 32-fold increased compared with nonsmoking noncarriers. (...)
Mots-clés Pascal : Résistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Infarctus, Myocarde, Facteur risque, Epidémiologie, Etude cas témoin, Washington, Etats Unis, Amérique du Nord, Amérique, Femelle, Adulte jeune, Homme, Hémopathie, Coagulopathie, Maladie héréditaire, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Facteur V Leiden
Mots-clés Pascal anglais : Resistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Infarct, Myocardium, Risk factor, Epidemiology, Case control study, Washington, United States, North America, America, Female, Young adult, Human, Hemopathy, Coagulopathy, Genetic disease, Cardiovascular disease, Coronary heart disease, Myocardial disease, Factor V Leiden
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0272183
Code Inist : 002B12A03. Création : 15/07/1997.