Combination Toxicology. European Conference. Veldhoven (NLD), 1995/10/11.
Regarding the risk evaluation of mixtures in the workplace, the Working Group discussed whether there is a need to consider combination effects at the workplace and whether there is sufficient information on combination toxicology to suggest a scientific strategy for the evaluation of any mixture at the workplace.
It was concluded that analytical definition of the mixture is a basic prerequisite for evaluation.
The Working Group agreed that there is a special situation at the workplace because chemical compounds may be present at concentrations close to their effective threshold level ; therefore, combination effects have to be taken into consideration, as shown by the data presented during the conference.
Furthermore, observed-effect levels for individual substances have to be modified if the substances have the same mode of action or have the same target organs ; no modification is necessary if the opposite has been shown.
It was also concluded that the scientific database to date is insufficient for the proposal of a general approach.
The assumption of additivity in all cases lacking data may more or less over-estimate the risk.
Mots-clés Pascal : Mélange, Association toxique, Exposition professionnelle, Médecine travail, Homme, Evaluation, Risque, Concentration maximale admissible
Mots-clés Pascal anglais : Mixture, Toxic association, Occupational exposure, Occupational medicine, Human, Evaluation, Risk, Maximum permissible concentration
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0268185
Code Inist : 002B03L01. Création : 15/07/1997.