This study was performed to survey the vitamin D nutritional status of urban Chinese women, and to define its role in determining bone metabolic rate and bone mineral density (BMD).
We measured serum 25-hydroxyvitamin D (25-OHD), the major storage form of vitamin D, and BMD, at the spine, hip, and total body skeleton, of 262 healthy Chinese women aged from 40 to 72 years, residing in Taipei city.
Bone turnover markers, including serum osteocalcin, bone alkaline phosphatase isozyme, and C-terminal propeptide of type I procollagen, and a urinary bone resorption marker, N-terminal crosslinked fragment of type I collagen, were also measured.
We found generally adequate vitamin D nutritional stores.
The mean concentration of serum 25-OHD was 30.7 (SD=8.2) ng/mL for all 262 subjects and there were no significant age-related changes.
Those who had serum sampled during the summer showed higher serum 25-OHD levels (N=138 ; mean ± SD : 32.7 ± 7.6 ng/mL) than those who had serum sampled during winter (N=124 ; mean ± SD : 28.5 ± 8.3 ng/mL ; Student's t-test, p<0.001), but these two groups showed similar BMD and bone marker values.
Those with serum 25-OHD concentration in the lowest or highest tertile did not show different BMD or bone marker values than those in the other tertiles.
Multiple regression demonstrated no correlation between 25-OHD and any bone marker or BMD at any site. (...)
Mots-clés Pascal : Densité, Os, Etat nutritionnel, Vitamine D, Concentration, Sérum, Spectrométrie absorption RX, Exploration, Remodelage osseux, Epidémiologie, Chinois, Homme, Femelle, Exploration radiologique, Milieu urbain, Double énergie
Mots-clés Pascal anglais : Density, Bone, Nutritional status, Vitamin D, Concentration, Serum, X ray absorption spectrometry, Exploration, Bone remodeling, Epidemiology, Chinese, Human, Female, Radiologic investigation, Urban environment, Dual energy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0264813
Code Inist : 002A23A. Création : 11/06/1997.