Racial differences in scleroderma among women in Michigan.
To examine racial differences in disease onset, extent, manifestations, and survival among women with scleroderma.
A retrospective cohort study of women with scleroderma, diagnosed in Michigan between 1980 and 1991, was conducted.
Clinical, laboratory, and demographic data were abstracted from the patients'medical records.
A total of 514 women with scleroderma were identified : 117 (23%) were black and 397 (77%) were white.
Among black women, the mean age at diagnosis was lower (44.5 years versus 51.5 years ; P<0.001) and diffuse disease was more common (49.6% versus 24.9% ; P<0.001) than among white women.
The overall incidence of scleroderma was 14.1 per million per year : 22.5 per million per year in black women versus 12.8 per million per year in white women (P<0.001).
Pericarditis (P=0.009), pulmonary hypertension (P<0.001), pleural effusions (P=0.01), myositis (P=0.02), and an erythrocyte sedimentation rate>40 mm/hour (P<0.001) were more frequent among black women, while white women were more likely to have digital infarctions (P<0.001).
Survival at 7 years from diagnosis was 72.5% among black women and 77.6% among white women.
Age-adjusted survival was significantly reduced among black women (P=0.033), most likely because of increased diffuse involvement.
Survival among those with renal or pulmonary involvement was also significantly reduced.
Mots-clés Pascal : Sclérodermie, Homme, Femelle, Epidémiologie, Incidence, Symptomatologie, Evolutivité, Pronostic, Etude comparative, Ethnie, Michigan, Etats Unis, Amérique du Nord, Amérique, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie
Mots-clés Pascal anglais : Scleroderma, Human, Female, Epidemiology, Incidence, Symptomatology, Evolutivity, Prognosis, Comparative study, Ethnic group, Michigan, United States, North America, America, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0264619
Code Inist : 002B07. Création : 11/06/1997.