Knee osteoarthritis (OA) is highly prevalent, especially in the elderly.
Preventive strategies require a knowledge of risk factors that precede disease onset.
The present study was conducted to determine the longitudinal risk factors for knee OA in an elderly population.
A longitudinal study of knee OA involving members of the Framingham Study cohort was performed.
Weight-bearing knee radiographs were obtained in 1983-1985 (baseline) and again in 1992-1993.
Incident disease was defined as the occurrence of new radiographic OA (Kellgren and Lawrence grade =2 on a 0-4 scale) in those without radiographic OA at baseline.
Risk factors assessed at baseline and in the interim were tested in univariate and multivariate equations to evaluate their association with incident knee OA.
Of 598 patients without knee OA at baseline (mean age 70.5 years, 63.7% women), 93 (15.6%) developed OA.
After adjustment for multiple risk factors, women had a higher risk of OA than did men (adjusted odds ratio [OR]=1.8,95% confidence interval [95% CI] 1.1-3.1).
Higher baseline body mass index increased the risk of OA (OR=1.6 per 5-unit increase, 95% CI 1.2-2.2), and weight change was directly correlated with the risk of OA (OR=1.4 per 10-1b change in weight, 95% CI 1.1-1.8).
Physical activity increased the risk of OA (for those in the highest quartile, OR=3.3,95% CI 1.4-7.5). (...)
Mots-clés Pascal : Arthrose, Genou, Vieillard, Homme, Epidémiologie, Facteur risque, Etude longitudinale, Radiographie, Exploration, Long terme, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Radiodiagnostic
Mots-clés Pascal anglais : Osteoarthritis, Knee, Elderly, Human, Epidemiology, Risk factor, Follow up study, Radiography, Exploration, Long term, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0264618
Code Inist : 002B15E. Création : 11/06/1997.