Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease.
To examine the role of low-grade inflammation in the etiology and progression of early osteoarthritis (OA) of the knee.
We used a new, high-sensitivity, automated monoclonal antibody immunoassay for the classic acute-phase protein, C-reactive protein (CRP), in serum.
Anteroposterior radiographs of the knee with weight bearing were obtained on 845 women (ages 44-67) on entry into a population-based study of OA in Chingford, North London.
In those defined radiologically as « cases, » the knee radiographs were repeated after 4 years.
Levels of CRP were higher in 105 women with knee OA defined radiologically as Kellgren-Lawrence grade 2+ (median 2.4 mg/liter, interquartile range [IQR] 1.0-5.1), compared with 740 women without OA (median 0.7 mg/liter, IQR 0.3-1.8) (P<0.001).
Median levels of CRP were higher in the 31 women whose disease progressed at least 1 Kellgren-Lawrence grade (median 2.6 mg/liter, IQR 1.9-4.6), compared with the 39 whose disease did not (median 1.3 mg/liter, IQR 0.6-2.4) (P=0.006).
The significance of these differences persisted after adjustment for age, weight, height, smoking, knee pain, or injury.
Classifying disease by the presence of joint space narrowing or osteophytes alone produced similar results.
Mots-clés Pascal : Arthrose, Genou, Homme, Epidémiologie, Phase initiale, Inflammation, Protéine C réactive, Concentration, Sérum, Faible, Niveau, Facteur prédictif, Evolutivité, Femelle, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative
Mots-clés Pascal anglais : Osteoarthritis, Knee, Human, Epidemiology, Early phase, Inflammation, C reactive protein, Concentration, Serum, Low, Level, Predictive factor, Evolutivity, Female, Diseases of the osteoarticular system, Arthropathy, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0264617
Code Inist : 002B15E. Création : 11/06/1997.