To measure the prevalence of colonization with antibiotic-resistant Gram-negative organisms and its association with potential risk factors, including antibiotic exposure, in a pediatric intensive care unit (ICU).
Prospective, observational study.
A 16-bed tertiary care pediatric ICU.
All children admitted to the pediatric ICU for>24 hrs over a 5-month period.
Two hundred ninety-six patients, approximately half of all patients admitted to the ICU, were enrolled in the study ; 236 patients had sufficient data collected for analysis and were prospectively examined for nasopharyngeal and gastrointestinal colonization by antibiotic-resistant Gram-negative organisms (ceftazidime minimal inhibitory concentration of>16 mug/mL, or tobramycin minimal inhibitory concentration>8 mug/mL).
Association between colonization and potential predisposing factors including demographics, diagnosis, Pediatric Risk of Mortality (PRISM) score, invasive instrumentation, and prior ICU antibiotic exposure was assessed.
More than 20% of patients were found to be colonized with an antibiotic-resistant Gram-negative organism.
Examination of the timing of colonization indicated that more than half were identified within 72 hrs of admission. (...)
Mots-clés Pascal : Antibiotique, Résistance, Bactérie Gram négatif, Infection nosocomiale, Unité soin intensif, Pédiatrie, Epidémiologie, Prévalence, Enfant, Homme
Mots-clés Pascal anglais : Antibiotic, Resistance, Gram negative bacteria, Nosocomial infection, Intensive care unit, Pediatrics, Epidemiology, Prevalence, Child, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0264527
Code Inist : 002B02S01. Création : 11/06/1997.