logo BDSP

Base documentaire


  1. Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands.

    Article - En anglais

    Objective 

    To compare the familial clustering of affective disorders among first-degree relatives of prepubertal versus adult probands with mood disorders.

    Method 

    The Family History-Research Diagnostic Criteria (FH-RDC) assessment instrument was used to obtain data on first-degree relatives of all probands.

    Logistic regression was used to assess the strength of the age of the proband to predict FH-RDC diagnoses in relatives.

    Survival analysis was used to examine the age-at-onset distribution of first FH-RDC diagnosis while controlling for year of birth.

    Results 

    The prevalence of major affective disorders was more than two times higher among first-degree relatives of child probands versus those of adult probands even when controlling for birth cohort.

    Cumulative risk for lifetime major mood disorders in first-degree relatives of child probands was significantly higher than for those of adult probands.

    Conclusion 

    These analyses further support that ascertainment of families through affected children identifies pedigrees with a higher proportion of affected relatives than ascertainment through affected adults.

    Mots-clés Pascal : Etat dépressif, Trouble bipolaire, Trouble humeur, Histoire familiale, Déterminisme génétique, Age apparition, Survie, Prévalence, Epidémiologie, Age scolaire, Enfant, Homme, Préadolescent, Adolescent, Adulte

    Mots-clés Pascal anglais : Depression, Bipolar disorder, Mood disorder, Family story, Genetic inheritance, Age of onset, Survival, Prevalence, Epidemiology, School age, Child, Human, Preadolescent, Adolescent, Adult

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0264374

    Code Inist : 002B18D09. Création : 11/06/1997.