Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands.
To compare the familial clustering of affective disorders among first-degree relatives of prepubertal versus adult probands with mood disorders.
The Family History-Research Diagnostic Criteria (FH-RDC) assessment instrument was used to obtain data on first-degree relatives of all probands.
Logistic regression was used to assess the strength of the age of the proband to predict FH-RDC diagnoses in relatives.
Survival analysis was used to examine the age-at-onset distribution of first FH-RDC diagnosis while controlling for year of birth.
The prevalence of major affective disorders was more than two times higher among first-degree relatives of child probands versus those of adult probands even when controlling for birth cohort.
Cumulative risk for lifetime major mood disorders in first-degree relatives of child probands was significantly higher than for those of adult probands.
These analyses further support that ascertainment of families through affected children identifies pedigrees with a higher proportion of affected relatives than ascertainment through affected adults.
Mots-clés Pascal : Etat dépressif, Trouble bipolaire, Trouble humeur, Histoire familiale, Déterminisme génétique, Age apparition, Survie, Prévalence, Epidémiologie, Age scolaire, Enfant, Homme, Préadolescent, Adolescent, Adulte
Mots-clés Pascal anglais : Depression, Bipolar disorder, Mood disorder, Family story, Genetic inheritance, Age of onset, Survival, Prevalence, Epidemiology, School age, Child, Human, Preadolescent, Adolescent, Adult
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0264374
Code Inist : 002B18D09. Création : 11/06/1997.