To compare 5 antihypertensive drugs and placebo for changes in quality of life (QL).
To assess the relationship of lifestyle factors and change in lifestyle factors to QL in participants with stage I diastolic hypertension.
The Treatment of Mild Hypertension Study (TOMHS) was a randomized, double-blind, placebo-controlled clinical trial with minimum participant follow-up of 4 years.
It was conducted at 4 hypertension screening and treatment academic centers in the United States.
The cohort consisted of 902 men and women with hypertension, aged 45 to 69 years, with diastolic blood pressures less than 100 mm Hg.
Informed consent was obtained from each participant after the nature of the procedures had been fully explained.
Sustained nutritional-hygienic intervention was administered to all participants to reduce weight, to reduce dietary sodium and alcohol intake, and to increase physical activity.
Participants were randomized to take (1) acebutolol (n=132) ; (2) amlodipine maleate (n=131) ; (3) chlorthalidone (n=126) ; (4) doxazosin mesylate (n=134) ; (5) enalapril maleate (n=135) ; or placebo (n=234).
Changes in 7 QL indexes were assessed based on a 35-item questionnaire :
(1) general health ;
(2) energy or fatigue ;
(3) mental health ;
(4) general functioning ;
(5) satisfaction with physical abilities ;
(6) social functioning ;
and (7) social contacts. (...)
Mots-clés Pascal : Hypertension artérielle, Traitement, Chimiothérapie, Antihypertenseur, Evaluation, Qualité vie, Corrélation, Efficacité traitement, Etude double insu, Homme, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Hypertension, Treatment, Chemotherapy, Antihypertensive agent, Evaluation, Quality of life, Correlation, Treatment efficiency, Double blind study, Human, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0263868
Code Inist : 002B02F05. Création : 11/06/1997.