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  1. Gene therapy : Basic concepts and applications in gastrointestinal diseases.

    Article - En anglais

    Molecular analyses have become an integral part of biomedical research as well as clinical medicine.

    The definition of the molecular and genetic basis of many human diseases has led not only to a better understanding of their pathogenesis, but has in addition offered new perspectives for their diagnosis, therapy, and prevention.

    Genetically, human diseases can be classified as monogenetic, complex genetic, and acquired genetic diseases.

    Based on this genetic classification, gene therapy involves four concepts : gene substitution, gene augmentation, block of gene expression or function as well as somatic transgene vaccination.

    Despite exciting recent developments, various delivery, targeting, and safety aspects need to be addressed before gene therapy will enter clinical practice.

    Clearly, molecular diagnosis and gene therapy of gastrointestinal diseases will be increasingly part of our patient management, complementing existing diagnostic, therapeutic, and preventive strategies.

    Mots-clés Pascal : Thérapie génique, Pathogénie, Maladie, Mécanisme action, Transfert génétique, Ciblage, Technique, Application, Appareil digestif, Article synthèse, Homme, Génétique, Appareil digestif pathologie

    Mots-clés Pascal anglais : Gene therapy, Pathogenesis, Disease, Mechanism of action, Genetic transfer, Targeting, Technique, Application, Digestive system, Review, Human, Genetics, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0263592

    Code Inist : 002A31D01D. Création : 11/06/1997.