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  1. Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure : The trials of hypertension prevention, phase II.

    Article - En anglais


    To provide a firmer basis for preventing high blood pressure (BP), we tested interventions to promote weight loss, dietary sodium reduction, and their combination for lowering diastolic BP, systolic BP, and the incidence of hypertension during a 3-to 4-year period.


    We conducted a randomized, 2 X 2 factorial, clinical trial, with BP levels measured by blinded observers.

    Nine academic medical centers recruited 2382 men and women (age range, 30-54 years) not taking antihypertensive drugs, with a diastolic BP of 83 to 89 mm Hg, a systolic BP lower than 140 mm Hg, and a body mass index (the weight in kilograms divided by the square of the height in meters) representing 110% to 165% of desirable body weight.

    Counseling aimed at helping participants achieve their desirable weight or a 4.5-kg or more weight reduction (in the weight loss and combined groups) and/or sodium intake of 80 mmol/d (in the sodium reduction and combined groups) was provided.


    From baseline, participants'weight decreased by 4.3 to 4.5 kg at 6 months and by approximately 2 kg at 36 months in the weight loss and combined groups compared with weight changes in the usual care group (all groups, P<. 001).

    Sodium excretion decreased 50 and 40 mmol/d at 6 and 36 months, respectively, in the sodium reduction group and about 15 mmol/d less at each time point in the combined group compared with the usual care group (all groups, P<. 01). (...)

    Mots-clés Pascal : Hypertension artérielle, Prévention, Effet biologique, Réduction, Poids corporel, Ingestion, Sodium, Incidence, Augmentation, Pression artérielle, Résultat, Homme, Appareil circulatoire pathologie, Traitement diététique

    Mots-clés Pascal anglais : Hypertension, Prevention, Biological effect, Reduction, Body weight, Ingestion, Sodium, Incidence, Increase, Arterial pressure, Result, Human, Cardiovascular disease, Diet therapy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0263351

    Code Inist : 002B12B05B. Création : 11/06/1997.