Organic Dust Toxic Syndrome (ODTS) is a flu-like syndrome that can occur after inhalation of cotton, grain, wood chip dusts, or other organic dusts or aerosols.
We investigated whether inflammatory pulmonary responses occur, even after relatively brief low-level wood chip mulch exposure.
Six volunteers were exposed to wood chip mulch dust.
Total dust and/or endotoxin levels were measured in five subjects.
Pulmonary function and peripheral blood counts were measured before and after exposure in each subject.
Bronchoalveolar lavage (BAL) was performed in each subject after exposure, and cell, cytokine, and protein concentrations were measured.
Control BAL without previous exposure was also performed on three of the subjects.
Three of six subjects had symptoms consistent with ODTS.
No clinically relevant or statistically significant changes in pulmonary function tests after exposure were found.
Three subjects manifested a marked elevation in neutrophil percentage in their BAL (range, 10 to 57%). When these three subjects underwent control BAL, the postexposure comparison demonstrated an increase in neutrophil levels of 154 ± 89 X 103/mL (mean ± standard error ; P=0.22).
The mean increase in BAL interleukin-8 levels after exposure, compared with paired control values, was 11.2 ± SE 2.5 pg/mL (P=0.047).
There was also an increase in BAL interleukin-6 levels that reached borderline significance (6.4 ± SE 2.0 pg/mL ; P=0.08). (...)
Mots-clés Pascal : Jardinier, Endotoxine, Surveillance biologique, Exposition professionnelle, Toxicité, Poussière, Matière organique, Décomposition, Paillage, Bois, Homme, Médecine travail, Inflammation, Poumon, Lavage bronchoalvéolaire, Fonction respiratoire, Appareil respiratoire pathologie, Cytokine, Volontaire
Mots-clés Pascal anglais : Gardener, Endotoxin, Biological monitoring, Occupational exposure, Toxicity, Dust, Organic matter, Decomposition, Mulching, Wood, Human, Occupational medicine, Inflammation, Lung, Bronchoalveolar lavage, Lung function, Respiratory disease, Cytokine, Volunteer
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0263032
Code Inist : 002B03L06. Création : 11/06/1997.