The refill records of computerized pharmacy systems are used increasingly as a source of complicance information.
We reviewed the English-language literature to develop a typology of methods for assessing refill compliance (RC), to describe the epidemiology to compliance in obtaining medications, to identify studies that attempted to validate RC measures, to describe clinical features athat predicted RC, and to describe the use of RC measures in epidemiologic and health services research.
In most of the 41 studies reviewed, patients obtained less medication than prescribed ; gaps in treatmen were common.
Of the studies that assessed the validity of RC measures, most found significant associations between RC and other compliance measures, as well as measures of drug presence (e.g., serum drug levels) or physiologic drug effects.
Refill compliance was generally not correlated with demographic characteristics of study populations, was higher among drugs with fewer daily doses, and was inconsistently associated with the total number of drugs prescribed.
We conclude that, though some methodologic problems require further study, RC measures can be a useful source of compliance information in population-based studies when direct measurement of medication consumption is not feasible.
Mots-clés Pascal : Observance médicamenteuse, Prescription médicale, Homme, Méthodologie, Epidémiologie, Validation, Médicament, Renouvellement ordonnance, Pharmacie officine
Mots-clés Pascal anglais : Drug compliance, Medical prescription, Human, Methodology, Epidemiology, Validation, Drug, Pharmacy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0259598
Code Inist : 002B30A01A1. Création : 11/06/1997.