Thrombin generation markers and coronary heart disease risk factors in a polish population sample.
Thrombosis plays a major role in the development of atherosclerosis and its acute vascular complications.
Epidemiological studies have shown that elevated levels of plasma fibrinogen are associated with an increased risk of coronary heart disease (CHD).
It is not clear whether this association is linked to hemostatic functions of fibrinogen which serves as a substrate for thrombin.
Generation of thrombin in vivo can be evaluated by measurement of its specific markers in plasma, i.e. thrombin-antithrombin III complex (TAT) and prothrombin fragment 1+2 (F1+2).
We determined plasma levels of TAT and F1+2 in a population sample of southeastern Poland and evaluated relations of these markers with plasma fibrinogen, factor VII coagulant activity (FVIIc), and other known CHD risk factors.
The population studied consisted of 215 men and 251 women, aged 43-75 years.
Final analysis was performed on 195 men and 222 women.
The distribution of plasma TAT and F1+2 concentrations were highly skewed with the higher median values for women than for men.
Log values of TAT correlated with log values of F1+2 in men (r=0.27, p<0.01) and in women (r=0.15, p<0.05).
In the regression analysis both markers were positively related to age in women but not in men.
After adjustment to age there was a positive relation between TAT and fibrinogen in both sexes.
In women, but not in men, F1+2 showed a positive association with FVllc. (...)
Mots-clés Pascal : Cardiopathie coronaire, Facteur risque, Epidémiologie, Thrombine, Antithrombine, Complexe enzyme inhibiteur, Prothrombine, Fragment peptidique, Fibrinogène, Facteur coagulation, Proconvertine, Marqueur biologique, Pologne, Europe, Homme, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Risk factor, Epidemiology, Thrombin(drug), Antithrombin, Inhibitor enzyme complex, Prothrombin, Peptide fragment, Fibrinogen, Coagulation factor, Factor VII, Biological marker, Poland, Europe, Human, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0259506
Code Inist : 002B12A03. Création : 11/06/1997.