GB virus-C/hepatitis G virus (GBV-C/HGV) is a newly identified flavivirus, and little is known about its clinical significance.
GBV-C/HGV was investigated in different populations, and its coinfection was investigated in patients with liver disease in Taiwan where hepatitis B and C are endemic.
Viral RNA was studied in 70 high-risk individuals, 20 patients with chronic non-B, non-C hepatitis, 13 with non-A-E fulminant hepatitis, 100 with asymptomatic hepatitis B surface antigen carriage, 120 with hepatitis B surface antigen-positive chronic liver disease and hepatocellular carcinoma, 100 patients with chronic hepatitis C, and 100 healthy adults.
GBV-C/HGV infection was more frequent in high-risk groups (15% - 30%) and hepatitis C virus carriers (10%) than in healthy adults (1%) and hepatitis B virus carriers (3.2%). Eighty-three percent of those infected had undergone blood transfusions previously.
The prevalence in hepatitis B virus carriers increased with the severity of liver disease, being 1% in asymptomatic carriers and 10% in hepatocellular carcinoma.
In chronic hepatitis C, clinical and virological data were comparable between those with and without coinfection.
In Taiwan, GBV-C/HGV infection is common in high-risk groups, and its coinfection seems to not aggravate the course of chronic hepatitis B or C.
Mots-clés Pascal : Hépatite virale, Virose, Infection, Incidence, Zone exposée, Carcinome hépatocellulaire, Endémie, Hépatite, Chronique, Facteur risque, Influence, Evolution, Epidémiologie, Homme, Taiwan, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Virus hépatite G
Mots-clés Pascal anglais : Viral hepatitis, Viral disease, Infection, Incidence, Exposed zone, Hepatocellular carcinoma, Endemy, Hepatitis, Chronic, Risk factor, Influence, Evolution, Epidemiology, Human, Taiwan, Asia, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0257734
Code Inist : 002B30A01B. Création : 11/06/1997.