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  1. GB virus-C/hepatitis G virus infection in an area endemic for viral hepatitis, chronic liver disease, and liver cancer.

    Article - En anglais

    Background & Aims 

    GB virus-C/hepatitis G virus (GBV-C/HGV) is a newly identified flavivirus, and little is known about its clinical significance.

    GBV-C/HGV was investigated in different populations, and its coinfection was investigated in patients with liver disease in Taiwan where hepatitis B and C are endemic.

    Methods 

    Viral RNA was studied in 70 high-risk individuals, 20 patients with chronic non-B, non-C hepatitis, 13 with non-A-E fulminant hepatitis, 100 with asymptomatic hepatitis B surface antigen carriage, 120 with hepatitis B surface antigen-positive chronic liver disease and hepatocellular carcinoma, 100 patients with chronic hepatitis C, and 100 healthy adults.

    Results 

    GBV-C/HGV infection was more frequent in high-risk groups (15% - 30%) and hepatitis C virus carriers (10%) than in healthy adults (1%) and hepatitis B virus carriers (3.2%). Eighty-three percent of those infected had undergone blood transfusions previously.

    The prevalence in hepatitis B virus carriers increased with the severity of liver disease, being 1% in asymptomatic carriers and 10% in hepatocellular carcinoma.

    In chronic hepatitis C, clinical and virological data were comparable between those with and without coinfection.

    Conclusions 

    In Taiwan, GBV-C/HGV infection is common in high-risk groups, and its coinfection seems to not aggravate the course of chronic hepatitis B or C.

    Mots-clés Pascal : Hépatite virale, Virose, Infection, Incidence, Zone exposée, Carcinome hépatocellulaire, Endémie, Hépatite, Chronique, Facteur risque, Influence, Evolution, Epidémiologie, Homme, Taiwan, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Virus hépatite G

    Mots-clés Pascal anglais : Viral hepatitis, Viral disease, Infection, Incidence, Exposed zone, Hepatocellular carcinoma, Endemy, Hepatitis, Chronic, Risk factor, Influence, Evolution, Epidemiology, Human, Taiwan, Asia, Digestive diseases, Hepatic disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0257734

    Code Inist : 002B30A01B. Création : 11/06/1997.