Hepatitis C virus is the leading cause of acute and chronic liver disease in hemodialysis patients.
There are at least six major HCV-genotypes, with a well documented geographical distribution in the general population.
Moreover, HCV-genotype is one of the major determinants of the therapeutic response to Interferon Alpha in affected patients.
Since the therapeutic outcome in HCV-positive hemodialysis patients, especially with regard to the different HCV-genotypes, is of interest, a multicentre epidemiologic study was performed in HCV-antibody positive hemodialysis patients of two geographically remote countries, i.e. in Flanders (Belgium) and in Saudi-Arabia. 184 chronic hemodialysis patients, with a positive second or third generation Elisa assay for HCV, were tested for HCV-viremia and HCV-genotype, using a 5'untranslated region (UR) nested PCR for the detection of HCV-RNA and subsequently type-specific probes to hybridize with HCV-RNA (Inno-Lipa).
Additionally, clinical data were collected by means of a standardized questionnaire, thoroughly completed by the nephrologist in charge of each respective patient.
Viremia was present in 79% of the patients (146 out of 184).
The prevalence of HCV-genotypes differed significantly between Belgian and Saudi-Arabian dialysis-patients.
In Belgian dialysis patients HCV-genotype 1b was most prevalent (i.e. (...)
Mots-clés Pascal : Insuffisance rénale, Chronique, Hémodialyse, Séropositivité, Virus hépatite C, Flaviviridae, Virus, Infection nosocomiale, Interféron, Belgique, Europe, Traitement, Complication, Homme, Arabie Saoudite, Asie, Etude comparative, Cytokine, Appareil urinaire pathologie, Rein pathologie, Epuration extrarénale, Immunopathologie, Immunodépresseur
Mots-clés Pascal anglais : Renal failure, Chronic, Hemodialysis, Seropositivity, Hepatitis C virus, Flaviviridae, Virus, Nosocomial infection, Interferon, Belgium, Europe, Treatment, Complication, Human, Saudi Arabia, Asia, Comparative study, Cytokine, Urinary system disease, Kidney disease, Extrarenal dialysis, Immunopathology, Immunosuppressive agent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0257275
Code Inist : 002B27B03. Création : 11/06/1997.