There is widespread acceptance that screening for lung cancer is not indicated, to our knowledge, because no randomized trial has demonstrated a reduction in mortality as a result of screening.
The objectives of this work are to review prospective studies on lung cancer screening and to analyze the extent to which known biases may have influenced observed results.
Four randomized controlled trials have been conducted.
The Memorial-Sloan Kettering and Johns Hopkins Lung Projects compared annual chest radiographs (CXRs) in a control group with CXRS and sputum apologia findings in an experimental group.
Although both studies failed to demonstrate any difference in outcome by the addition of cytologic study to CXR, long-term survival in both studies was approximately three times that predicted by other data.
Accordingly, these results are at least consistent with the hypothesis that the screening CXRs may have improved survival.
Two randomized trials, the Mayo Lung Project and the Czechoslovak study, compared regular and frequent rescreening CXRs in an experimental group with sporadic and/or infrequent rescreening in a control group.
Both the Mayo and Czech studies demonstrated a striking advantage for screening with respect to stage distribution, resectability, survival, and fatality.
Nevertheless, mortality was somewhat higher in the screened groups in both studies. (...)
Mots-clés Pascal : Carcinome, Bronchopulmonaire, Dépistage, Radiographie, Thorax, Etats Unis, Amérique du Nord, Amérique, Exploration, Diagnostic, Homme, Article synthèse, Survie, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne, Radiodiagnostic
Mots-clés Pascal anglais : Carcinoma, Bronchopulmonary, Medical screening, Radiography, Thorax, United States, North America, America, Exploration, Diagnosis, Human, Review, Survival, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0256674
Code Inist : 002B11A. Création : 11/06/1997.