Lung cancer in relation to exposure to silica dust, silicosis and uranium production in South African gold miners.
A nested case-control study for lung cancer was performed on a cohort of 2260 South African gold miners in whom an association between exposure to silica dust and risk of lung cancer was previously reported.
The objective was to investigate an expanded set of risk factors and also cancer cell type.
The 78 cases of lung cancer found during the follow up period from 1970 to 1986 were matched with 386 controls.
Risk of lung cancer was related to smoking, exposure to silica dust, incidence of silicosis, and uranium production and the uranium content of the mine ore.
The risk of lung cancer was associated with tobacco smoking, cumulative dust exposure, duration of underground mining, and with silicosis.
The best predictive model included pack years of cigarette consumption (adjusted relative risk (RR)=1.0 for<6.5 pack years, 3.5 (95% confidence interval (CI) 0.7 to 16.8) for 6.5-20 pack years, 5.7 (95% CI 1.3 to 25.8) for 21-30 pack years, and 13.2 (95% CI 3.1 to 56.2) for more than 30 pack years) and silicosis (RR=2.45 (95% CI 1.2 to 5.2)). No association was found with uranium production.
The lung tumour cell type distribution was 40.3% small cell carcinoma, 38.8% squamous cell, 16.4% adenocarcinoma, and 4.5% large cell carcinoma.
Small and large cell cancer combined were associated with exposure to dust.
The results cannot be interpreted definitively in terms of causal association. (...)
Mots-clés Pascal : Carcinome, Bronchopulmonaire, Silicose, Mineur, Silice, Uranium, République Sud Africaine, Afrique, Facteur risque, Complication, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne, Exposition professionnelle, Maladie professionnelle, Pneumoconiose
Mots-clés Pascal anglais : Carcinoma, Bronchopulmonary, Silicosis, Minor, Silica, Uranium, South Africa, Africa, Risk factor, Complication, Human, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor, Occupational exposure, Occupational disease, Pneumoconiosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0255949
Code Inist : 002B11A. Création : 11/06/1997.