Experimental and epidemiologic investigations suggest that alpha-tocopherol (the most prevalent chemical form of vitamin E found in vegetable oils, seeds, grains, nuts, and other foods) and bêta-carotene (a plant pigment and major precursor of vitamin A found in many yellow, orange, and dark-green, leafy vegetables and some fruit) might reduce the risk of cancer, particularly lung cancer.
The initial findings of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) indicated, however, that lung cancer incidence was increased among participants who received bêta-carotene as a supplement.
Similar results were recently reported by the Beta-Carotene and Retinol Efficacy Trial (CARET), which tested a combination of bêta-carotene and vitamin A. Purpose : We examined the effects of alpha-tocopherol and bêta-carotene supplementation on the incidence of lung cancer across subgroups of participants in the ATBC Study defined by base-line characteristics (e.g., age, number of cigarettes smoked, dietary or serum vitamin status, and alcohol consumption), by study compliance, and in relation to clinical factors, such as disease stage and histologic type.
Our primary purpose was to determine whether the pattern of intervention effects across subgroups could facilitate further interpretation of the main ATBC Study results and shed light on potential mechanisms of action and relevance to other populations. (...)
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Incidence, alpha-Tocophérol, Vitamine, Bétacarotène, Chimioprophylaxie, Prévention, Epidémiologie, Finlande, Europe, Antioxydant, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Incidence, alpha-Tocopherol, Vitamin, Betacarotene, Chemoprophylaxis, Prevention, Epidemiology, Finland, Europe, Antioxidant, Human, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0253690
Code Inist : 002B11A. Création : 11/06/1997.