Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders.
Humans vary in their ability to metabolize endogenous and exogenous compounds.
Glutathione S-transferases (GSTs) and N-acetyltrans-ferases (NATs) are enzymes involved in the detoxification of hazardous agents.
The GSTMI and GSTT1 genes exhibit null (i.e., deletion) polymorphisms ; in specific individuals, homozygous deletion (i.e., both copies lost) of these genes can be detected.
Polymorphism of the NAT2 gene results in slow and fast acetylators of potentially toxic substances.
The GSTMI-null and the NAT2 slow-acetylator genotypes have been associated with increased risks for the development of environmentally induced cancers.
We assessed whether homozygous GSTMI-null or GSTT1-null genotypes or the NAT2 slow-acetylator genotype were associated with increased risks for the development of malignant and nonmalignant asbestos-related pulmonary disorders in a cohort of Finnish construction workers.
The study population consisted of 145 asbestos insulators who were classified as having been exposed to high levels of asbestos ; 69 of these individuals had no pulmonary disorders (control subjects), and 76 had either malignant mesothelioma (n=24) or nonmalignant pulmonary disorders, such as asbestosis and/or pleural plaques (n=52).
Lymphocyte DNA and the polymerase chain reaction were used to determine the GSTMI, GSTT1, and NAT2 genotypes of the study subjects. (...)
Mots-clés Pascal : Mésothéliome malin, Asbestose, Facteur risque, Epidémiologie, Glutathione transferase, Transferases, Enzyme, Arylamine N-acetyltransferase, Acyltransferases, Génotype, Finlande, Europe, Exposition professionnelle, Amiante, Homme, Tumeur maligne, Plèvre pathologie, Appareil respiratoire pathologie, Pneumoconiose, Maladie professionnelle, Poumon pathologie
Mots-clés Pascal anglais : Malignant mesothelioma, Asbestosis, Risk factor, Epidemiology, Glutathione transferase, Transferases, Enzyme, Arylamine N-acetyltransferase, Acyltransferases, Genotype, Finland, Europe, Occupational exposure, Asbestos, Human, Malignant tumor, Pleural disease, Respiratory disease, Pneumoconiosis, Occupational disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0253686
Code Inist : 002B11A. Création : 11/06/1997.