Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy.
Human evidence that ionizing radiation is carcinogenic first came from reports of nonmelanoma skin cancers (NMSCs) on the hands of workers using early radiation devices.
An increased risk of NMSC has been observed among uranium miners, radiologists, and individuals treated with x rays in childhood for tinea capitis (ringworm of the scalp) or for thymic enlargement ; NMSC is one of the cancers most strongly associated with the atomic bombing of Hiroshima and Nagasaki.
Although exposure to ionizing radiation is a known cause of NMSC, it is not yet clear whether therapeutic radiation causes both major histologic types of NMSC, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
Additionally, the potentially modifying effects, such as latency, age when treated, and type of treatment, are not well understood.
We investigated the relative risks of BCC and SCC associated with previous radiation therapy and evaluated these risks in relation to age and time since initial treatment and the medical condition for which radiation therapy was given.
The study group comprised individuals diagnosed with at least one BCC or SCC from January 1980 through February 1986, who were recruited to participate in a skin cancer prevention trial designed to test whether oral bêta-carotene supplementation would reduce the risk of new NMSCs. (...)
Mots-clés Pascal : Carcinome basocellulaire, Carcinome épidermoïde, Peau, Facteur risque, Radiothérapie, Epidémiologie, Complication, Etats Unis, Amérique du Nord, Amérique, Homme, Peau pathologie, Tumeur maligne
Mots-clés Pascal anglais : Basal cell carcinoma, Squamous cell carcinoma, Skin, Risk factor, Radiotherapy, Epidemiology, Complication, United States, North America, America, Human, Skin disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0253685
Code Inist : 002B08A. Création : 11/06/1997.