Risk factors for lung Cancer and for intervention effects in caret, the Beta-Carotene and Retinol Efficacy Trial.
Evidence has accumulated from observational studies that people eating more fruits and vegetables, which are rich in bêta-carotene (a violet to yellow plant pigment that acts as an antioxidant and can be converted to vitamin A by enzymes in the intestinal wall and liver) and retinol (an alcohol chemical form of vitamin A), and people having higher serum bêta-carotene concentrations had lower rates of lung cancer.
The Beta-Carotene and Retinol Efficacy Trial (CARET) tested the combination of 30 mg bêta-carotene and 25 000 IU retinyl palmitate (vitamin A) taken daily against placebo in 18 314 men and women at high risk of developing lung cancer.
The CARET intervention was stopped 21 months early because of clear evidence of no benefit and substantial evidence of possible harm ; there were 28% more lung cancers and 17% more deaths in the active intervention group (active=the daily combination of 30 mg bêta-carotene and 25000 IU retinyl palmitate).
Promptly after the January 18,1996, announcement that the CARET active intervention had been stopped, we published preliminary findings from CARET regarding cancer, heart disease, and total mortality.
We present for the first time results based on the pre-specified analytic method, details about risk factors for lung cancer, and analyses of subgroups and of factors that possibly influence response to the intervention. (...)
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Facteur risque, Bétacarotène, Rétinol, Antioxydant, Epidémiologie, Chimioprophylaxie, Prévention, Etats Unis, Amérique du Nord, Amérique, Vitamine, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Risk factor, Betacarotene, Retinol, Antioxidant, Epidemiology, Chemoprophylaxis, Prevention, United States, North America, America, Vitamin, Human, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0253315
Code Inist : 002B11A. Création : 11/06/1997.