To determine the prevalence of thrombocytopenia in a group of patients suffering from the antiphospholipid syndrome (APS) and to investigate whether these patients may have any particular clinical or serological features.
A group of 171 APS patients seen in our department were studied for the presence of thrombocytopenia.
Clinical and serological features of these patients were analysed by standard methods and each of them was correlated to the presence of thrombocytopenia and compared with those found in the group without thrombocytopenia.
Each of the patients studied had a minimum of three platelet counts during the follow up period.
Forty (23.4%) were found to have thrombocytopenia ; 13 with persistently low and 27 patients with intermittently low platelet counts.
There were no statistically significant differences in sex, age, disease duration or diagnosis when compared with the group of APS patients without thrombocytopenia.
Thrombocytopenia was associated with thrombosis in 18, with miscarriages in five, and with both of these features in 13 patients.
It was the only manifestation of the APS in four patients.
All patients had persistently positive tests for antiphospholipid antibodies concomitantly with the low platelet counts.
No significant association was found between the presence of thrombocytopenia and clinical or serological manifestations in APS patients. (...)
Mots-clés Pascal : Antiphospholipide syndrome, Homme, Association, Thrombopénie, Symptomatologie, Analyse biochimique, Epidémiologie, Prévalence, Analyse corrélation, Thrombocyte, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Hémopathie, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Antiphospholipid antibody syndrome, Human, Association, Thrombocytopenia, Symptomatology, Biochemical analysis, Epidemiology, Prevalence, Correlation analysis, Platelet, Cardiovascular disease, Vascular disease, Hemopathy, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0251871
Code Inist : 002B07. Création : 11/06/1997.