High prevalence of Sjögren's syndrome in patients with HTLV-I associated myelopathy.
A high seroprevalence of HTLV-I in female Sjögren's syndrome (SS) patients has been reported in Nagasaki, Japan, an area that is heavily endemic for HTLV-I infection.
Salivary IgA class antibodies to HTLV-I were common among HTLV-I seropositive patients with SS.
This study was undertaken to elucidate the pathogenesis of SS caused by HTLV-I infection.
Methods-The clinical features and histological findings of SS and the prevalence of serum autoantibodies in 10 patients with HTLV-I associated myelopathy (HAM) who were consecutively admitted into Nagasaki University School of Medicine, were compared with those of 20 HTLV-I seropositive and 20 HTLV-I seronegative patients with SS.
Ocular and oral manifestations of SS were commonly detected in HAM patients.
These patients also had extraglandular manifestations including recurrent uveitis, arthropathy, interstitial pneumonitis, Raynaud's phenomenon, and inflammatory bowel disease.
All patients with HAM histologically showed a mononuclear cell infiltration in the labial salivary grands.
Six of 10 patients had a mononuclear cell infiltration with a focus score of 1 or greater.
According to the preliminary criteria for SS proposed by the European Community, definitive SS was diagnosed in six patients and probable SS in two patients.
Serum y globulin and IgG values were increased in HAM patients. (...)
Mots-clés Pascal : Sjogren syndrome, Homme, Femelle, Epidémiologie, Prévalence, Infection, Myélopathie, Association, Virus HTLV1, Retroviridae, Virus, Pathogénie, Japon, Asie, Analyse biochimique, Immunohistochimie, Oeil pathologie, Stomatologie, Maladie système, Immunopathologie, Maladie autoimmune, Système nerveux pathologie, Moelle épinière pathologie, Anatomopathologie, Histopathologie
Mots-clés Pascal anglais : Sjogren syndrome, Human, Female, Epidemiology, Prevalence, Infection, Myelopathy, Association, HTLV-I virus, Retroviridae, Virus, Pathogenesis, Japan, Asia, Biochemical analysis, Immunohistochemistry, Eye disease, Stomatology, Systemic disease, Immunopathology, Autoimmune disease, Nervous system diseases, Spinal cord disease, Pathology, Histopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0251865
Code Inist : 002B07. Création : 11/06/1997.